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Watch Carefully (1)pentobarbital will reduce the level or influence of levamlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the level or influence of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration. Robust or average CYP3A inducers ma